I've been hearing news about friends and relatives having nephrotic problems. It's quite alarming and saddening to learned that. It's not easy to have kidney problems. I think that's one big problem to have. Perhaps most of them may have problems with their creatinine levels and so some may have to reduce it while the others needed more. As for the latter they have to find the best creatine supplements to help them with it. I hope these guys may recover ASAP.